I just saw this, and I’m so excited I can barely contain myself. This is like being there at the discovery of penicillin.
MIT researchers have found a way to cure viral diseases, any viral diseases, from common colds through dengue and up to HIV. (Press release, PLoS One research article.) This is one huge, massive, “Wow!”
Rider drew inspiration for his therapeutic agents, dubbed DRACOs (Double-stranded RNA Activated Caspase Oligomerizers), from living cells’ own defense systems.
When viruses infect a cell, they take over its cellular machinery for their own purpose — that is, creating more copies of the virus. During this process, the viruses create long strings of double-stranded RNA (dsRNA), which is not found in human or other animal cells. …
Rider had the idea to combine a dsRNA-binding protein with another protein that induces cells to undergo apoptosis (programmed cell suicide) — launched, for example, when a cell determines it is en route to becoming cancerous. Therefore, when one end of the DRACO binds to dsRNA, it signals the other end of the DRACO to initiate cell suicide.
And here’s the result:
What that shows is DRACO did not damage healthy cells at all. That’s the top row of each set of images. Infected cells, the bottom row, died without treatment (the lower left images in each set), and were indistinguishable from healthy ones with treatment (the lower right images).
Can you imagine? We could just laugh at viruses! Ebola? Hahahaha! (As I say, I’m a mite over-excited.)